Phenotyping of transgenic and KO mice
(Drug target validation)
The human genome sequence offers a large pool of potential new drug targets to address unmet medical needs and to improve current therapies. One way to test whether a given gene could be a valuable drug target is to generate knock-out or transgenic mice. The thorough analysis of these genetically modified mice reveals whether the phenotype mimics a human disease.
Phenotyping starts with the analysis of blood parameters and a histopathological evaluation of 40 organs. The results on the nature of the affected organs guide subsequent further detailed analyses.
Morphome are complete packages used to evaluate the phenotypes of genetically modified mice.
MORPHOME™ Discovery: a comprehensive histopathological analysis including physiology for both sexes.
MORPHOME™ Junior: focused on developmental defects in prenatal and postnatal specimens, from E9.5 to P6.
MORPHOME™ System: a comprehensive macroscopic and histopathological analysis of all representative organs of a given functional system.
Service number 8000.00: Physiological Parameters:
- Hematology: blood counts, coagulation
- Blood Chemistry: metabolites, enzymes, electrolytes (Chemogram up to 20 parameters of your choice)
- Urine Status: proteins, sediment, test strip